Genomic epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in New Zealand

RS Lee; T Seemann; H Heffernan; JC Kwong; A Gonçalves Da Silva; GP Carter; R Woodhouse; KH Dyet; DM Bulach; TP Stinear; BP Howden; DA Williamson

Journal article

Genomic epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in New Zealand

RS Lee, T Seemann, H Heffernan, JC Kwong, A Gonçalves Da Silva, GP Carter, R Woodhouse, KH Dyet, DM Bulach, TP Stinear, BP Howden, DA Williamson

Journal of Antimicrobial Chemotherapy | OXFORD UNIV PRESS | Published : 2018

DOI: 10.1093/jac/dkx405

Download PDF

Abstract

Background: Antimicrobial-resistant Neisseria gonorrhoeae is a major threat to public health. No studies to date have examined the genomic epidemiology of gonorrhoea in the Western Pacific Region, where the incidence of gonorrhoea is particularly high. Methods: A population-level study of N. gonorrhoeae in New Zealand (October 2014 to May 2015). Comprehensive susceptibility testing and WGS data were obtained for 398 isolates. Relatedness was inferred using phylogenetic trees, and pairwise core SNPs. Mutations and genes known to be associated with resistance were identified, and correlated with phenotype. Results: Eleven clusters were identified. In six of these clusters, >25% of isolates wer..

View full abstract

University of Melbourne Researchers

Torsten Seemann Author

Jason Kwong Author

Glen Carter Author

Dieter Bulach Author

Related Projects (3)

ESTABLISHING THE USE OF BACTERIAL GENOMICS IN AUSTRALIA

We propose to establish a set of fully assembled reference genomes through new technologies and methods to analyse data from high throughput..

IMPROVING PREVENTION, TRACKING AND TREATMENT OF MAJOR HUMAN BACTERIAL PATHOGENS

This research fellowship will lead to a detailed understanding of the mechanisms by which bacteria become resistant to antibiotics and cause..

UNDERSTANDING, REDUCING AND PREVENTING COMMUNICABLE DISEASES USING APPLIED PATHOGEN GENOMICS

Infectious diseases are a major threat to human health. New molecular methods, particularly whole genome sequencing, promise a revolution in..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

R. S. L. is supported by a Fellowship from the Canadian Institutes of Health Research (Funding Reference Number 152448). B. P. H. has a Practitioner Fellowship from the National Health and Medical Research Council, Australia (GNT1105905). J. C. K. is supported by a postgraduate scholarship from the National Health and Medical Research Council (GNT1074824). D. A. W. is supported by an Early Career Fellowship, also from the National Health and Medical Research Council (GNT1123854). This study was funded by the Ministry of Health of New Zealand. The Microbiological Diagnostic Unit Public Health Laboratory is funded by the Victorian Government, Australia.